The effect of biomaterials and antifungals on biofilm formation by Candida species: a review

被引:59
作者
Cuellar-Cruz, M. [1 ]
Vega-Gonzalez, A. [2 ]
Mendoza-Novelo, B. [2 ]
Lopez-Romero, E. [3 ]
Ruiz-Baca, E. [4 ]
Quintanar-Escorza, M. A. [5 ]
Villagomez-Castro, J. C. [3 ]
机构
[1] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Unidad Biotecnol Med & Farmaceut, Guadalajara 44270, Jalisco, Mexico
[2] Univ Guanajuato, Dept Ingn Quim & Elect Biomed, Div Ciencias & Ingn, Guanajuato, Mexico
[3] Univ Guanajuato, Dept Biol, Div Ciencias Nat & Exactas, Guanajuato, Mexico
[4] Univ Juarez Estado Durango, Dept Biol Celular & Mol, Fac Ciencias Quim, Durango, Mexico
[5] Univ Juarez Estado Durango, Fac Med & Nutr, Victoria De Durango, Durango, Mexico
关键词
DIFFERENTIAL GENE-EXPRESSION; HUMAN-IMMUNODEFICIENCY-VIRUS; MULTIDRUG-RESISTANCE GENE; CDNA MICROARRAY ANALYSIS; FUNGAL DRUG-RESISTANCE; GENOME-WIDE EXPRESSION; AZOLE RESISTANCE; FLUCONAZOLE RESISTANCE; ALBICANS BIOFILMS; IN-VITRO;
D O I
10.1007/s10096-012-1634-6
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are able to form biofilms on virtually any biomaterial implanted in a human host. Biofilms are a primary cause of mortality in immunocompromised and hospitalized patients, as they cause recurrent and invasive candidiasis, which is difficult to eradicate. This is due to the fact that the biofilm cells show high resistance to antifungal treatments and the host defense mechanisms, and exhibit an excellent ability to adhere to biomaterials. Elucidation of the mechanisms of antifungal resistance in Candida biofilms is of unquestionable importance; therefore, this review analyzes both the chemical composition of biomaterials used to fabricate the medical devices, as well as the Candida genes and proteins that confer drug resistance.
引用
收藏
页码:2513 / 2527
页数:15
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