Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010-2018

被引：19

作者：

Nishijima, Takeshi ^{[1
,2
]}

Kawana, Kei ^{[3
]}

Fukasawa, Ichio ^{[4
]}

Ishikawa, Naoko ^{[2
]}

Taylor, Melanie M. ^{[5
,6
]}

Mikamo, Hiroshige ^{[7
]}

Kato, Kiyoko ^{[8
]}

Kitawaki, Jo ^{[9
]}

Fujii, Tomoyuki ^{[10
]}

机构：

[1] Natl Ctr Global Hlth & Med, Tokyo, Japan

[2] World Hlth Org, Reg Off Western Pacific, Manila, Philippines

[3] Nihon Univ, Sch Med, Tokyo, Japan

[4] Dokkyo Med Univ, Mibu, Tochigi, Japan

[5] World Hlth Org, Geneva, Switzerland

[6] Ctr Dis Control & Prevent, Atlanta, GA USA

[7] Aichi Med Univ, Nagakute, Aichi, Japan

[8] Kyushu Univ, Grad Sch Med Sci, Fukuoka, Japan

[9] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kyoto, Japan

[10] Univ Tokyo, Grad Sch Med, Tokyo, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2020年 / 26卷 / 06期

关键词：

CONGENITAL-SYPHILIS; CEFTRIAXONE; EMPHASIS;

D O I：

10.3201/eid2606.191300

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted a nationwide retrospective study In Japan to evaluate the effectiveness of oral amoxicillin or ampicillin as alternatives to injectable benzathine penicillin G for treating pregnant women with syphilis and preventing congenital syphilis (CS). We investigated 80 pregnant women with active syphilis treated with amoxicillin or ampicillin during 2010-2018. Overall, 21% (15/71) had pregnancies resulting in CS cases, and 3.8% (3/80) changed therapies because of side effects. Among 26 patients with early syphilis, no CS cases occurred, but among 45 with late syphilis, 15 (33%) CS cases occurred. Among 57 patients who started treatment >= 60 days before delivery, 8 (14%) had CS pregnancy outcomes. We found oral arnoxicillin potentially ineffective for preventing CS cases among pregnant women with late syphilis but potentially effective in those with early syphilis. Prospective studies are needed to definitively evaluate the efficacy of amoxicillin for the treatment of pregnant women with syphilis to prevent CS.

引用

页码：1192 / 1200

页数：9

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