Early Childhood Shigellosis and Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study with a Prolonged Follow-up

被引：11
作者：
Merzon, Eugene [1 ,2 ]
Gutbir, Yuval [4 ,6 ]
Vinker, Shlomo [1 ,2 ]
Cohen, Avivit Golan [1 ,3 ]
Horwitz, Dana [5 ,7 ]
Ashkenazi, Shai [8 ,9 ]
Sadaka, Yair [4 ,7 ]
机构：
[1] Leumit HMO, Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Dept Family Med, Tel Aviv, Israel
[3] Tel Aviv Univ, Tel Aviv, Israel
[4] Ben Gurion Univ Negev, Beer Sheva, Israel
[5] Ben Gurion Univ Negev, Med Studies, Beer Sheva, Israel
[6] Hadassah Ein Karem Hosp, Pediat, Jerusalem, Israel
[7] Mental Hlth Inst, Beer Sheva, Israel
[8] Ariel Univ, Pediat, Ariel, Israel
[9] Ariel Univ, Adelson Sch Med, Ariel, Israel
来源：
JOURNAL OF ATTENTION DISORDERS | 2021年 / 25卷 / 13期
关键词：
ADHD; childhood shigellosis; gastroenteritis; WHITE-MATTER; CONVULSIONS; PREVALENCE; ENCEPHALOPATHY; INVOLVEMENT; CHILDREN; ADHD;
D O I：
10.1177/1087054720940392
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Background: Although the short-term neurological complications ofShigellaspp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. Methods: This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5-18 years who underwent stool culture prior to the age of 3 years. Results: Of 52,761 children with a stool culture examined, 5,269 (9.98%) hadShigella-positive results. The rate of ADHD was 10.6% and 8.6% among children withShigella-positive andShigella-negative stool cultures, respectively (p< .001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13-1.29,p< .001). The younger the child was duringShigellagastroenteritis, the higher was the association with ADHD (p< .001). Conclusion: Early childhood shigellosis is associated with an increased rate of long-term ADHD.
引用
收藏
页码：1791 / 1800
页数：10
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