Role of mepolizumab in severe allergic asthma with vocal cord polyp

被引：0
作者：
Karim, Azmat [1 ]
Shameem, Mohammd [1 ]
Khan, Abdul Allam [2 ]
机构：
[1] Aligarh Muslim Univ, Dept Resp Med, Jawahar Lal Nehru Med Coll & Hosp, Aligarh, Uttar Pradesh, India
[2] Fortis Escorts Heart Inst, Cardiol, New Delhi, India
来源：
LUNG INDIA | 2022年 / 39卷 / 06期
关键词：
Mepolizumab; severe eosinophilic asthma; vocal cord polyp; EFFICACY; THERAPY;
D O I：
10.4103/lungindia.lungindia_272_22
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Interleukin (IL)-5 plays an important role in development, recruitment, and survival of eosinophils, thereby causing debilitating signs and symptoms associated with severe eosinophilic asthma. Mepolizumab is a humanized monoclonal antibody (mAb) against IL-5 which selectively inhibits eosinophilic inflammation and reduces the amount of eosinophils. This reduction is seen in both sputum and blood, resulting in a reduction in exacerbations and in time the need for using systemic steroids. The role of mepolizumab and its effect is still not fully known as there are less real-life studies available. We herewith present a case of severe eosinophilic asthma with vocal polyp managed by mepolizumab.
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页码：578 / 580
页数：3
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