Assessment of reactor-produced 199Au as a promising theranostic radionuclide and subsequent separation from platinum target

被引：7

作者：

Attallah, Mohamed F. ^{[1
]}

Gizawy, Mohamed A. ^{[2
,3
]}

Shamsel-Din, Hesham A. ^{[2
,3
]}

Mohamed, Nader M. A. ^{[4
]}

Ali, Amal M., I ^{[5
]}

机构：

[1] Atom Energy Author, Analyt Chem & Control Dept, Hot Labs Ctr, POB 13759, Cairo, Egypt

[2] Atom Energy Author, Res Reactor ETRR 2 2, Radioisotopes Prod Facil RPF, POB 13759, Cairo, Egypt

[3] Atom Energy Author, Labeled Cpds Dept, Hot Labs Ctr, POB 13759, Cairo, Egypt

[4] Atom Energy Author, Atom Reactors Dept, POB 13759, Cairo, Egypt

[5] Atom Energy Author Egypt, Technol Nucl Fuel Dept, Hot Labs Ctr, POB 13759 Abu Zaabal, Cairo, Egypt

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2020年 / 325卷 / 02期

关键词：

Nuclear reaction; Radioisotope production; Chemical separation; Sorption and ion exchange; Au-199; INDUCED NUCLEAR-REACTIONS; CROSS-SECTION DATA; IRRADIATED PLATINUM; NANOPARTICLES; ANTIBODIES; THERAPY; GOLD;

D O I：

10.1007/s10967-020-07257-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Feasibility of(199)Au production from neutron activated platinum and gold targets at the Egyptian Second Research Reactor was studied. A comparison between theoretical calculations and experimental measurements for the two targets was carried out. A radiochemical separation of(199)Au from irradiated Pt target was achieved using chromatographic column packed with modified chabazite material with elution efficiency of 90 +/- 0.54% based on the high separation factor between Au and other produced undesired radionuclides. Three quality control tests; radionuclidic, radiochemical and chemical purities were carried out on the eluted(199)Au to ensure its safe application in nuclear medicine.

引用

页码：447 / 452

页数：6

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