Identification of Urinary and Feces Metabolites of Rhizoma Paridis Saponins in rats based on Ultra High Performance Liquid Chromatography/Time-Of-Flight Mass Spectrometry (UPLC/Q-TOF/MS)

被引：0

作者：

Wu, Shanshan ^{[1
]}

Gao, Wenyuan ^{[1
]}

Man, Shuli ^{[1
]}

Liu, Changxiao ^{[2
]}

Wei, Jinchao ^{[3
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China

[2] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Sch Chinese Med, Tianjin 300193, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2011年 / 30卷 / 10期

关键词：

Metabolites; Rat urine and feces; Rhizoma Paridis saponins; UPLC/Q-TOF/MS; POLYPHYLLA; PLASMA;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS) method was established to analyze the saponins in Rhizoma Paridis saponins (RPS) and the constituents in urinary and feces samples. As we know, the constituents of traditional Chinese medicines are very complex and pre-clinical research including metabolism, excretion and pharmacokinetics of herbal medicine components are of great importance in understanding their biological effects and safety. Therefore, deduction of the metabolic and excretive processes of RPS are necessary. As a result, twenty-two original saponins were detected in RPS-treated urinary and feces. Four excreta were observed in rat feces. Therefore, most original saponins and little deglycosylated saponins have been excreted In the rat urine and feces.

引用

页码：1927 / 1933

页数：7

共 11 条

[1]

[Anonymous], STRAIT PHARM J

[2] Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells [J].

Cheng, Zhi-Xiang ;

Liu, Bao-Rui ;

Qian, Xiao-Ping ;

Ding, Yi-Tao ;

Hu, Wen-Jing ;

Sun, Jing ;

Yu, Li-Xia .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 120 (02) :129-137

[3] Detection of saponins in extracts from the rhizomes of Paris species and prepared Chinese medicines by high performance liquid chromatography-electrospray ionization mass spectrometry [J].

Liu, Hai ;

Huang, Yun ;

Wang, Qiang ;

Zhang, Ting ;

Song, Yue .

PLANTA MEDICA, 2006, 72 (09) :835-841

[4] Analysis of lignans in Schisandra chinensis and rat plasma by high-performance liquid chromatography diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry [J].

Lou, Ziyang ;

Zhang, Hai ;

Gong, Chungui ;

Zhu, Zhenyu ;

Zhao, Liang ;

Xu, Yuanjie ;

Wang, Bin ;

Zhang, Guoqing .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2009, 23 (06) :831-842

[5] Identification of chemical constituents in Rhizoma Paridis Saponins and their oral administration in rat plasma by UPLC/Q-TOF/MS [J].

Man, Shuli ;

Gao, Wenyuan ;

Zhang, Yanjun ;

Huang, Luqi ;

Liu, Changxiao .

BIOMEDICAL CHROMATOGRAPHY, 2011, 25 (06) :712-719

[6] Antitumor and antimetastatic activities of Rhizoma Paridis saponins [J].

Man, Shuli ;

Gao, Wenyuan ;

Zhang, Yanjun ;

Yan, Lulu ;

Ma, Chaoyi ;

Liu, Changxiao ;

Huang, Luqi .

STEROIDS, 2009, 74 (13-14) :1051-1056

[7] Characterization of steroidal saponins in saponin extract from Paris polyphylla by liquid chromatography tandem multi-stage mass spectrometry [J].

Man, Shuli ;

Gao, Wenyuan ;

Zhang, Yanjun ;

Jin, Xinghua ;

Ma, Chaoyi ;

Huang, Xianxiao ;

Li, Qingyun .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 395 (02) :495-505

[8]

Wang Y., 2006, ASIAN J TRADIT MED, V1, P7

[9]

Yan L. L., 2009, Experimental Oncology, V31, P27

[10]

Yang L., 2011, LAT AM J PHARM, V30, P487

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