RNA recognition by the Vts1p SAM domain

被引：54
|
作者：
Johnson, PE
Donaldson, LW
机构：
[1] York Univ, Dept Chem, N York, ON M3J 1P3, Canada
[2] York Univ, Dept Biol, N York, ON M3J 1P3, Canada
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 02期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nsmb1039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p - SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.
引用
收藏
页码：177 / 178
页数：2
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