Synthesis, spectroscopic characterization and computational study of Ru(II)/DMSO complexes with monocoordinated carbazate ligands

被引：2
作者：
Sousa, Luana M. [1 ]
Araujo, Diesley M. S. [2 ]
Oliveira, Katia M. [3 ]
De Oliveira, Leticia P. [3 ]
Maia, Pedro I. S. [4 ]
Deflon, Victor M. [5 ]
Batista, Alzir A. [3 ]
Machado, Antonio E. H. [1 ,6 ]
Guerra, Wendell [1 ]
Von Poelhsitz, Gustavo [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Quim, Uberlandia, MG, Brazil
[2] Inst Fed Triangulo Mineiro, Ituiutaba, MG, Brazil
[3] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP, Brazil
[4] Univ Fed Triangulo Mineiro, Dept Quim, Uberaba, MG, Brazil
[5] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP, Brazil
[6] Univ Fed Catalao, Programa Posgrad Ciencias Exatas & Tecnol, Unidade Acad Especial Fis, Catalao, Go, Brazil
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2020年 / 73卷 / 10期
关键词：
Carbazates; cytotoxicity; DFT calculations; Ru(II) complexes; X-ray structure; CRYSTAL-STRUCTURES; COORDINATION-COMPOUNDS; RU(II)-DMSO COMPLEXES; CHEMICAL BEHAVIOR; DNA-BINDING; RUTHENIUM; TOXICITY; BASES; DRUG;
D O I：
10.1080/00958972.2020.1777286
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reaction of the precursorcis,fac-[RuCl2(dmso-S)(3)(dmso-O)] with three carbazate ligands led to new compounds of the typecis,fac-[RuCl2(dmso-S)(3)(L)] (L = benzylcarbazate (bc),1; 4-methoxybenzylcarbazate (mc),2; or 3,5-dimethoxy-alpha,alpha-dimethylbenzylcarbazate (mmc),3). Complexes1-3have been characterized by elemental analysis (CHN), FTIR, UV-vis, and(1)H and(13)C{H-1} NMR spectroscopy. Complex1was also analyzed by single-crystal X-ray diffraction and theoretical calculations were performed in order to better understand its spectroscopic data and electronic structure. All collected data were consistent with substitution of one dmso ligand by a monodentate carbazate ligand. Preliminary biological assays against breast and prostate human cancer cell lines were performed in order to evaluate the cytotoxic activity of these three new complexes.
引用
收藏
页码：1605 / 1618
页数：14
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