Tick-borne encephalitis virus natural foci emerge in western Sweden

被引：27

作者：

Brinkley, Catherine ^{[1
]}

Nolskog, Peter ^{[2
]}

Golovljova, Irina ^{[3
]}

Lundkvist, Ake ^{[3
]}

Bergstrom, Tomas ^{[1
]}

机构：

[1] Gothenburg Univ, Dept Virol, S-41346 Gothenburg, Sweden

[2] Cent Hosp Skovde, Dept Infect Dis, S-54185 Skovde, Sweden

[3] Swedish Inst Infect Dis Control, Stockholm, Sweden

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2008年 / 298卷

关键词：

flavivirus; tick-borne encephalitis virus; RT-PCR; ticks; molecular epidemiology;

D O I：

10.1016/j.ijmm.2007.12.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There has been an emergence of tick-borne encephalitis (TBE) cases in western Sweden over the past 10 years. Human cases cluster in distinct regions around major bodies of water, raising the question of TBE prevalence in ticks within these defined localities. This study was based on a collection of 7120 questing nymphs, 5 10 questing adults, and 132 fed female ticks from cows in 4 suspected TBE foci, based on human cases, and 2 non-endemic areas of western Gotaland. All tick pools were screened with Real-Time RT-PCR targeting the non-coding 3'-region. Prevalence in ticks in the endemic areas ranged from 0.1 % to 0.42%, which is comparable with other more established TBE endemic regions in Europe. Of the 18 positive pools, viral COPY numbers ranged from 500 to 3.7 x 10(9) copies/pool. Sequence data from a TBE patient in western Gotaland confirmed that the western European Subtype of TBEV has spread to western Sweden. (c) 2008 Elsevier GmbH. All rights reserved.

引用

页码：73 / 80

页数：8

共 45 条

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