Stem cell therapy for neurological disorders: A focus on aging

被引：46
作者：
Hung Nguyen [1 ]
Zarriello, Sydney [1 ]
Coats, Alexandreya [1 ]
Nelson, Cannon [1 ]
Kingsbury, Chase [1 ]
Gorsky, Anna [1 ]
Rajani, Mira [1 ]
Neal, Elliot G. [1 ]
Borlongan, Cesar V. [1 ]
机构：
[1] Univ S Florida, Morsani Coll Med, Dept Neurosurg & Brain Repair, Ctr Excellence Aging & Brain Repair, Tampa, FL 33612 USA
来源：
NEUROBIOLOGY OF DISEASE | 2019年 / 126卷
关键词：
Age-related brain disorders; Neurodegenerative diseases; Stroke; Traumatic brain injury; Cell-therapy; TRAUMATIC BRAIN-INJURY; AMYOTROPHIC-LATERAL-SCLEROSIS; MESENCHYMAL STROMAL CELLS; HYPOXIC-ISCHEMIC INJURY; FOCAL CEREBRAL-ISCHEMIA; PHASE-I TRIAL; PARKINSONS-DISEASE; HEMATOPOIETIC STEM; PROGENITOR CELLS; RODENT MODEL;
D O I：
10.1016/j.nbd.2018.09.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options.
引用
收藏
页码：85 / 104
页数：20
相关论文
共 210 条
[1]   In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells [J].
Abati, Elena ;
Di Fonzo, Alessio ;
Corti, Stefania .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (05) :2536-2546
[2]   Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke [J].
Acosta, Sandra A. ;
Tajiri, Naoki ;
Hoover, Jaclyn ;
Kaneko, Yuji ;
Borlongan, Cesar V. .
STROKE, 2015, 46 (09) :2616-2627
[3]   Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury [J].
Acosta, Sandra A. ;
Tajiri, Naoki ;
Shinozuka, Kazutaka ;
Ishikawa, Hiroto ;
Sanberg, Paul R. ;
Sanchez-Ramos, Juan ;
Song, Shijie ;
Kaneko, Yuji ;
Borlongan, Cesar V. .
PLOS ONE, 2014, 9 (03)
[4]   Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging [J].
Aksoy, Ceren ;
Kaya, Fatima Aerts ;
Kuskonmaz, Bulent Baris ;
Uckan, Duygu ;
Severcan, Feride .
AGE, 2014, 36 (04)
[5]   GDNF, NGF and BDNF as therapeutic options for neurodegeneration [J].
Allen, Shelley J. ;
Watson, Judy J. ;
Shoemark, Deborah K. ;
Barua, Neil U. ;
Patel, Nikunj K. .
PHARMACOLOGY & THERAPEUTICS, 2013, 138 (02) :155-175
[6]   Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells [J].
Altarche-Xifro, Wassim ;
di Vicino, Umberto ;
Isabel Munoz-Martin, Maria ;
Bortolozzi, Analia ;
Bove, Jordi ;
Vila, Miquel ;
Pia Cosma, Maria .
EBIOMEDICINE, 2016, 8 :83-95
[7]   Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient [J].
Amariglio, Ninette ;
Hirshberg, Abraham ;
Scheithauer, Bernd W. ;
Cohen, Yoram ;
Loewenthal, Ron ;
Trakhtenbrot, Luba ;
Paz, Nurit ;
Koren-Michowitz, Maya ;
Waldman, Dalia ;
Leider-Trejo, Leonor ;
Toren, Amos ;
Constantini, Shlomi ;
Rechavi, Gideon .
PLOS MEDICINE, 2009, 6 (02) :221-231
[8]   Potential for Cell Therapy in Parkinson's Disease Using Genetically Programmed Human Embryonic Stem Cell-Derived Neural Progenitor Cells [J].
Ambasudhan, Rajesh ;
Dolatabadi, Nima ;
Nutter, Anthony ;
Masliah, Eliezer ;
McKercher, Scott R. ;
Lipton, Stuart A. .
JOURNAL OF COMPARATIVE NEUROLOGY, 2014, 522 (12) :2845-2856
[9]  
[Anonymous], 2012, CHALL NEUR DIS
[10]   Motor and cognitive improvements in patients with Huntington's disease after neural transplantation [J].
Bachoud-Lévi, A ;
Rémy, P ;
Nguyen, JP ;
Brugières, P ;
Lefaucheur, JP ;
Bourdet, C ;
Baudic, S ;
Gaura, V ;
Maison, P ;
Haddad, B ;
Boissé, MF ;
Grandmougin, T ;
Jény, R ;
Bartolomeo, P ;
Dalla Barba, G ;
Degos, JD ;
Lisovoski, F ;
Ergis, AM ;
Pailhous, E ;
Cesaro, P ;
Hantraye, P ;
Peschanski, M .
LANCET, 2000, 356 (9246) :1975-1979
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