Human cancer, PTEN and the PI-3 kinase pathway

被引：182
作者：
Parsons, R
机构：
[1] Columbia Univ, Inst Canc Genet, Dept Pathol, New York, NY USA
[2] Columbia Univ, Dept Med, Inst Canc Genet, New York, NY USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 02期
关键词：
human cancer; PI-3; kinase; PTEN;
D O I：
10.1016/j.semcdb.2003.12.021
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The PI-3 kinase pathway is a major driving force for human cancer. One common way of stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor suppressor. The mechanisms of PTEN inactivation include mutation, epigenetic silencing and post-translational modification. Improved insight into the regulation of PTEN is leading to a richer understanding of the contribution of PTEN and the PI-3 kinase pathway to human tumors. Understanding the pathology of PI-3 kinase signaling in tumors improves knowledge of cancer etiology and provides novel therapeutic targets. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：171 / 176
页数：6
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