PD-L1 controls cancer pyroptosis

被引：21

作者：

Blasco, Maria Teresa ^{[1
]}

Gomis, Roger R. ^{[1
,2
,3
,4
]}

机构：

[1] Barcelona Inst Sci & Technol, Canc Sci Program, Inst Res Biomed IRB Barcelona, Barcelona, Spain

[2] CIBERONC, Madrid, Spain

[3] Univ Barcelona, Barcelona, Spain

[4] ICREA Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

来源：

NATURE CELL BIOLOGY | 2020年 / 22卷 / 10期

关键词：

TUMOR HYPOXIA; ANGIOGENESIS;

D O I：

10.1038/s41556-020-00582-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Programmed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form of cell death, by activating the expression of Gasdermine C, ultimately leading to tumour necrosis.

引用

页码：1157 / 1159

页数：3

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