Tumor metastasis: moving new biological insights into the clinic

被引：644

作者：

Wan, Liling ^{[1
]}

Pantel, Klaus ^{[2
]}

Kang, Yibin ^{[1
,2
,3
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[2] Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Dept Tumour Biol, Ctr Med Expt, Hamburg, Germany

[3] Canc Inst New Jersey, New Brunswick, NJ USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 11期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER METASTASIS; LUNG ADENOCARCINOMA METASTASIS; MINIMAL RESIDUAL CANCER; BONE-MARROW; PROSTATE-CANCER; COLORECTAL-CANCER; STEM-CELLS; EXTRACELLULAR-MATRIX; PANCREATIC-CANCER;

D O I：

10.1038/nm.3391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.

引用

页码：1450 / 1464

页数：15

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