Mitochondrial Signaling: Retrograde Regulation in Yeast Saccharomyces cerevisiae

被引:1
|
作者
Yurina, N. P. [1 ]
Odintsova, M. S. [1 ]
机构
[1] Russian Acad Sci, Bach Inst Biochem, Moscow 119071, Russia
基金
俄罗斯基础研究基金会;
关键词
D O I
10.1134/S102279540811001X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The review considers the current views of the yeast signaling system that connects mitochondria with the nucleus and is known as retrograde regulation. The adaptive character of this signaling system is emphasized. The system is activated upon damage to mitochondrial functions (e.g., by stress or mutations) and is aimed at adapting the cell to the changed functional state of the organelles. The retrograde signaling system is controlled by positive (Rtg1p, Rtg2p, Rtg3p, and Grr1p) and negative (Mks1p, Lst8p, Bmh1p, and Bmh2p) regulatory factors. The possibility of several retrograde pathways existing in mitochondria is discussed in brief. Data on some functions of retrograde regulation are described.
引用
收藏
页码:1251 / 1257
页数:7
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