New inhibitors of α-glucosidase in Salacia hainanensis Chun et How

被引：11

作者：

Guo, Zheng-hong ^{[1
]}

Huang, Jian ^{[2
]}

Wan, Guo-sheng ^{[2
]}

Huo, Xiao-ling ^{[2
]}

Gao, Hui-Yuan ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Vocat & Tech Sch, Shenyang 110026, Peoples R China

[2] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design, Discovery Minist Educ, Shenyang 110016, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2013年 / 67卷 / 04期

关键词：

Salacia hainanensis Chun et How; Inhibitors of alpha-glucosidase; New triterpenoids; TRITERPENOIDS; BIOCHEMISTRY;

D O I：

10.1007/s11418-013-0744-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2 beta,3 beta,22 alpha-trihydroxy-lup-20(29)-ene (2) and 3 beta-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4-9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards alpha-glucosidase than the positive control (acarbose, IC50 10.2 mu M).

引用

页码：844 / 849

页数：6

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