Engineering of composite particles for drug delivery using supercritical fluid technology

被引：0
|
作者：
Shekunov, BY [1 ]
Chattopadhyay, P [1 ]
Seitzinger, J [1 ]
机构：
[1] Ferro Corp, Pharmaceut Technol, Independence, OH 44131 USA
来源：
POLYMERIC DRUG DELIVERY II: POLYMERIC MATRICES AND DRUG PARTICLE ENGINEERING | 2006年 / 924卷
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D O I：
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Challenges associated with the production of micro- and nanoparticles for drug delivery can be addressed using supercritical fluids (SCFs) or liquefied gases. These fluids offer the benefits of low processing temperatures, efficient organic solvent extraction, environmentally benign processing and cost effectiveness. In this chapter, we discuss the different technological approaches which employ SCFs, in relation to potential applications such as manufacturing of particulate systems for controlled or sustained release, coating and taste-masking, respiratory formulations and nanoparticles for increased solubilization.
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页码：234 / 249
页数：16
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