Fabrication and Application of Noble Metal NanocompositesBased Surface-Enhanced Raman Scattering Active Substrate

With the rapid development of nanotechnology and laser technology, surface-enhanced Raman scattering ( SERS) technology has flourished with a great leap. As an analysis and detection technology for fast, nondestructive, and ultra- sensitive response to the fingerprint information of the target molecule, SERS technology has been widely applied in the field of food detection, environmental monitoring and clinical diagnosis. Fabrication of SERS substrate is the committed step of achieving the ultra- sensitive detection in various fields using SERS technology. At present, the SERS activity, homogeneity, and other properties of SERS substrates which are constructed by single noble metal nanomaterials through complex and timeconsuming methods cannot fit the demand of the point-of-care detection in various fields. Therefore, more and more research scholars focus on the development of simple and rapid methods to fabrication of multi-functional composite SERS substrates and application of these composite SERS substrates into the field of food detection, environmental monitoring and clinical diagnosis. This article mainly reviews the preparation of precious metal composite SERS substrates and their applications in the past years, discusses and analyzes the function and application advantages of multi-functional composite SERS substrates. The forecast of multi-functional composite SERS substrate is also provided at the end of this article.