Neurogenesis in adult human

被引：78

作者：

Murrell, W

Bushell, GR

Livesey, J

McGrath, J

MacDonald, KPA

Bates, PR

MackaySim, A

机构：

[1] GRIFFITH UNIV, SCH BIOMOL & BIOMED SCI, NATHAN, QLD 4111, AUSTRALIA

[2] PRINCESS ALEXANDRA HOSP, DEPT SURG, WOOLLOONGABBA, QLD 4102, AUSTRALIA

[3] WOLSTON PK HOSP, CLIN STUDIES UNIT, WACOL, QLD 4076, AUSTRALIA

来源：

NEUROREPORT | 1996年 / 7卷 / 06期

关键词：

neurogenesis; human olfactory mucosa; growth factor; brain development; neurodevelopmental disorders; Alzheimer's disease; schizophrenia;

D O I：

10.1097/00001756-199604260-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not glial proteins. [H-3]thymidine autoradiography confirmed that these neurones were born in vitro. The results demonstrate that the adult human olfactory epithelium retains the capacity for neurogenesis and neuronal differentiation, at least until the age of 72 years. It is now possible to examine neurones and neurogenesis in biopsies from patients with disorders that may involve a neurodevelopmental or neurodegenerative aetiology such as schizophrenia, bipolar disorder and Alzheimer's disease.

引用

页码：1189 / 1194

页数：6

共 26 条

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