Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

被引：62

作者：

Albrecht, B. ^{[1
,2
]}

Brandeis, D. ^{[2
,3
,4
,5
,6
]}

Uebel, H. ^{[1
]}

Valko, L. ^{[3
]}

Heinrich, H. ^{[7
,8
]}

Drechsler, R. ^{[3
]}

Heise, A. ^{[1
]}

Mueller, U. C. ^{[3
,9
]}

Steinhausen, H. -C. ^{[3
,10
,11
]}

Rothenberger, A. ^{[1
]}

Banaschewski, T. ^{[2
]}

机构：

[1] Univ Gottingen, D-37075 Gottingen, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[3] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland

[4] Univ Zurich, Ctr Integrat Human Physiol, Zurich, Switzerland

[5] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[6] ETH, Zurich, Switzerland

[7] Univ Erlangen Nurnberg, Dept Child & Adolescent Mental Hlth, Erlangen, Germany

[8] Heckscher Klin, Munich, Germany

[9] Interkantonale Hsch Heilpadagog Zurich, Zurich, Switzerland

[10] Aarhus Univ Hosp, Aalborg Psychiat Hosp, Aalborg, Denmark

[11] Univ Basel, Dept Clin Psychol & Epidemiol, Basel, Switzerland

来源：

PSYCHOLOGICAL MEDICINE | 2013年 / 43卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

Attention deficit-hyperactivity disorder; contingent negative variation; Continuous Performance Test; endophenotypes; event-related potentials; NoGo-P3; CONTINUOUS PERFORMANCE-TEST; EVENT-RELATED POTENTIALS; CONTINGENT NEGATIVE-VARIATION; AGE-RELATED-CHANGES; DEFICIT/HYPERACTIVITY DISORDER; CONDUCT DISORDER; BRAIN-FUNCTION; MOTOR CONTROL; ADHD; CHILDREN;

D O I：

10.1017/S003329171200270X

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method. Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43). Results. Children with ADHD and non-affected siblings showed more variable performance and made more omission errors than controls. The preparatory Cue-P3 and contingent negative variation (CNV) following cues were reduced in both ADHD children and their non-affected siblings compared with controls. The NoGo-P3 was diminished in ADHD compared with controls whilst non-affected siblings were located intermediate but did not differ from both other groups. No clear familiality effects were found for the Go-P3. Better task performance was further associated with higher CNV and P3 amplitudes. Conclusions. Impairments in performance and electrophysiological parameters reflecting preparatory processes and to some extend also for inhibitory response control, especially under high attentional load, appeared to be familially driven in ADHD and may thus constitute functionally relevant endophenotypes for the disorder.

引用

页码：1997 / 2011

页数：15

共 81 条

[11] Annotation: What electrical brain activity tells us about brain function that other techniques cannot tell us - a child psychiatric perspective [J].