DORSAL RAPHE NUCLEUS;
MONOAMINE-OXIDASE-A;
5-HT1A RECEPTOR AGONISTS;
NORMAL ANXIETY-LIKE;
RAT-BRAIN SLICES;
SOCIAL INSTIGATION;
GENE PROMOTER;
BEHAVIOR;
POLYMORPHISM;
INHIBITION;
D O I:
10.1523/JNEUROSCI.2067-12.2013
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Numerous studies link decreased serotonin metabolites with increased impulsive and aggressive traits. However, although pharmacological depletion of serotonin is associated with increased aggression, interventions aimed at directly decreasing serotonin neuron activity have supported the opposite association. Furthermore, it is not clear if altered serotonin activity during development may contribute to some of the observed associations. Here, we used two pharmacogenetic approaches in transgenic mice to selectively and reversibly reduce the firing of serotonin neurons in behaving animals. Conditional overexpression of the serotonin 1A receptor (Htr1a) in serotonin neurons showed that a chronic reduction in serotonin neuron firing was associated with heightened aggression. Overexpression of Htr1a in adulthood, but not during development, was sufficient to increase aggression. Rapid suppression of serotonin neuron firing by agonist treatment of mice expressing Htr1a exclusively in serotonin neurons also led to increased aggression. These data confirm a role of serotonin activity in setting thresholds for aggressive behavior and support a direct association between low levels of serotonin homeostasis and increased aggression.
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Bonnavion, Patricia
Bernard, Jean-Francois
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Bernard, Jean-Francois
Hamon, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Hamon, Michel
Adrien, Joelle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Adrien, Joelle
Fabre, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Caspi, A
McClay, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
McClay, J
Moffitt, TE
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h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Moffitt, TE
Mill, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Mill, J
Martin, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Martin, J
Craig, IW
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Craig, IW
Taylor, A
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Taylor, A
Poulton, R
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Bonnavion, Patricia
Bernard, Jean-Francois
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Bernard, Jean-Francois
Hamon, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Hamon, Michel
Adrien, Joelle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Adrien, Joelle
Fabre, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
Univ Paris 06, INSERM, U677, F-75013 Paris, FranceUniv Paris 06, Fac Med Pierre & Marie Curie, IFR Neurosci 70, UMR S677, F-75013 Paris, France
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Caspi, A
McClay, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
McClay, J
Moffitt, TE
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Moffitt, TE
Mill, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Mill, J
Martin, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Martin, J
Craig, IW
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Craig, IW
Taylor, A
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Taylor, A
Poulton, R
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England