REACTIONS OF 3-AMINO-5-METHYLISOXAZOLE WITH ENOL ETHERS: SYNTHESIS OF NEW ISOXAZOLYLENAMINES DERIVATIVES AND SUBSTITUTED ISOXAZOLO[2,3-a]PYRIMIDINONES

被引：0

作者：

Al-Ayed, Abdullah Soliman ^{[1
]}

Khalfallah, Ali ^{[2
]}

Kaddachi, Mohamed Tahar ^{[1
]}

机构：

[1] Univ Qassim 53 Al Rass, Dept Chem, Fac Sci & Arts, Al Rass, Saudi Arabia

[2] Univ Gabes, Appl Organ Chem Lab, Dept Chem, Fac Sci, Gabes 6072, Tunisia

来源：

REVUE ROUMAINE DE CHIMIE | 2012年 / 57卷 / 11期

关键词：

3-amino-5-methylisoxazole; ethoxymethylenemalonate; ethoxymethylenecyano-acetate; isoxazolo[2,3]pyrimidinones; isoxazolylenamines; IN-VITRO; ACIDS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of isoxazolylenamines and substituted isoxazolo[2,3-a]pyrimidinones were prepared via condensation of ethoxymethylenemalonate 2a-d and ethoxymethylenecyanoacetate 2e-h with 3-amino-5-methylisoxazole 1. When reactions were carried out under reflux in xylene, the thermal cyclisation of isoxazolylenamines intermediates 3a-d afforded exclusively the isoxazolo[2,3-a]pyrimidinones 4a-d. All the synthesized compounds were characterized by elemental analysis, MS, IR and NMR spectrometry.

引用

页码：901 / 906

页数：6