Regulation of B-cell function by NF-kappaB c-Rel in health and disease

被引：15

作者：

Basavarajappa, Shrikanth C. ^{[1
]}

Ramakrishnan, Parameswaran ^{[1
,2
,3
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Dept Pathol,Sch Med, 6526,Wolstein Res Bldg,2103 Cornell Rd, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 17期

关键词：

B lymphocytes; Transcription; Antibody production; Lymphoma; Autoimmunity; GERMINAL CENTER B; TRANSCRIPTION FACTORS; MICE LACKING; MALIGNANT TRANSFORMATION; LYMPHOCYTE-PROLIFERATION; TRANSACTIVATION DOMAIN; NUCLEAR ACCUMULATION; CYCLE PROGRESSION; GENE-EXPRESSION; DNA-BINDING;

D O I：

10.1007/s00018-020-03488-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-kappa B) family of transcription factors play a major role in regulating B-cell functions. NF-kappa B subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.

引用

页码：3325 / 3340

页数：16

共 129 条

[51] B lymphocytes differentially use the Rel and nuclear factor κB1 (NF-κB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells [J].