Sphingosine 1-Phosphate in Renal Diseases

被引：42
|
作者：
Koch, Alexander [1 ]
Pfeilschifter, Josef [1 ]
Huwiler, Andrea [2 ]
机构：
[1] Klinikum Johann Wolfgang Goethe Univ, ZAFES, Pharmazentrum Frankfurt, Frankfurt, Germany
[2] Univ Bern, Inst Pharmacol, Bern, Switzerland
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2013年 / 31卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
Sphingosine; 1-phosphate; Kidney disease; Diabetic nephropathy; Glomerulonephritis; Ischemia-reperfusion injury; Wilms tumor; TISSUE GROWTH-FACTOR; ISCHEMIA-REPERFUSION INJURY; SMAD SIGNALING CASCADE; WILMS-TUMOR CELLS; MESANGIAL CELLS; PROXIMAL TUBULE; FUNCTIONAL-CHARACTERIZATION; DIABETIC-NEPHROPATHY; MEDIATES PROTECTION; KINASE TYPE-2;
D O I：
10.1159/000350093
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression. Copyright (c) 2013 S. Karger AG, Basel
引用
收藏
页码：745 / 760
页数：16
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