Reduced serum beta-trace protein is associated with metabolic syndrome

被引：7
作者：
Cheung, Ching-Lung [1 ]
Cheung, Tommy T. [1 ]
Lam, Karen S. L. [2 ,3 ]
Cheung, Bernard M. Y. [1 ,3 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Div Clin Pharmacol & Therapeut, Pokfulam, Hong Kong, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Div Endocrinol & Metab, Pokfulam, Hong Kong, Peoples R China
[3] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Res Ctr Heart Brain Hormone & Hlth Aging, Pokfulam, Hong Kong, Peoples R China
来源：
ATHEROSCLEROSIS | 2013年 / 227卷 / 02期
关键词：
Diabetes; Metabolic syndrome; Beta-trace protein; Biomarker; NHANES III; PROSTAGLANDIN D SYNTHASE; EXPRESSION; PGD(2); HEART; MICE;
D O I：
10.1016/j.atherosclerosis.2013.01.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: beta-trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS). Methods: Data on 3136 participants aged >20 years of the National Health and Nutrition Examination Survey III were examined. Logistic regression was used to assess the association of BTP with diabetes and MetS. Results: Reduced levels of BTP were associated with diabetes and MetS in age, sex, and race/ethnicity adjusted models. After further multivariable adjustment, BTP levels in quartile 1 remained significantly associated with MetS (odds ratio 2.04 [95% CI 1.14-3.70], P-trend = 0.003) when compared with quartile 4. Among the five components of MetS, BTP was associated with hypertriglyceridemia (P-trend < 0.001) but not diabetes (P-trend = 0.099). Conclusion: MetS is associated with a reduced serum level of BTP. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：404 / 407
页数：4
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