Controlling and Monitoring Orientation of DNA Nanoconstructs on Lipid Surfaces

被引：14

作者：

Lundberg, Erik P. ^{[1
]}

Feng, Bobo ^{[1
]}

Mohammadi, Amir Saeid ^{[1
]}

Wilhelmsson, L. Marcus ^{[1
]}

Norden, Bengt ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Chem & Biol Engn Phys Chem, SE-41296 Gothenburg, Sweden

来源：

LANGMUIR | 2013年 / 29卷 / 01期

基金：

欧洲研究理事会;

关键词：

REDUCED DICHROISM CURVES; LINEAR DICHROISM; VESICLE FUSION; NUCLEIC-ACIDS; FINITE-SIZE; ORIGAMI; ENERGY; MOLECULE; NANOSTRUCTURES; CONSTRUCTION;

D O I：

10.1021/la304178f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Its extraordinary self-assembly property, with potential to form nonperiodic structures with unique addressability, makes DNA ideal for fabrication of advanced nanostructures. We here demonstrate the controllable tethering of a hexagonal DNA nanostructure in two distinct orientations at the lipid bilayer of a liposome functioning as a soft-matter support. With polarized light (linear dichroism) applied to the flow-aligned liposomes, we show that the construct is preferentially in a parallel alignment with the lipid surface when two anchors are attached while with one anchor only a perpendicular orientation is observed.

引用

页码：285 / 293

页数：9

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