Controlling and Monitoring Orientation of DNA Nanoconstructs on Lipid Surfaces

被引：14
|
作者：
Lundberg, Erik P. [1 ]
Feng, Bobo [1 ]
Mohammadi, Amir Saeid [1 ]
Wilhelmsson, L. Marcus [1 ]
Norden, Bengt [1 ]
机构：
[1] Chalmers Univ Technol, Dept Chem & Biol Engn Phys Chem, SE-41296 Gothenburg, Sweden
来源：
LANGMUIR | 2013年 / 29卷 / 01期
基金：
欧洲研究理事会;
关键词：
REDUCED DICHROISM CURVES; LINEAR DICHROISM; VESICLE FUSION; NUCLEIC-ACIDS; FINITE-SIZE; ORIGAMI; ENERGY; MOLECULE; NANOSTRUCTURES; CONSTRUCTION;
D O I：
10.1021/la304178f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Its extraordinary self-assembly property, with potential to form nonperiodic structures with unique addressability, makes DNA ideal for fabrication of advanced nanostructures. We here demonstrate the controllable tethering of a hexagonal DNA nanostructure in two distinct orientations at the lipid bilayer of a liposome functioning as a soft-matter support. With polarized light (linear dichroism) applied to the flow-aligned liposomes, we show that the construct is preferentially in a parallel alignment with the lipid surface when two anchors are attached while with one anchor only a perpendicular orientation is observed.
引用
收藏
页码：285 / 293
页数：9
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