The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

被引：36

作者：

Sanabria, Angela ^{[1
,2
]}

Alegret, Montserrat ^{[1
,2
]}

Rodriguez-Gomez, Octavio ^{[1
,2
]}

Valero, Sergi ^{[3
]}

Sotolongo-Grau, Oscar ^{[1
,2
]}

Monte-Rubio, Gemma ^{[1
,2
]}

Abdelnour, Carla ^{[1
,2
]}

Espinosa, Ana ^{[1
,2
]}

Ortega, Gemma ^{[1
,2
]}

Perez-Cordon, Alba ^{[1
,2
]}

Gailhajanet, Anna ^{[1
,2
]}

Hernandez, Isabel ^{[1
,2
]}

Rosende-Roca, Maitee ^{[1
,2
]}

Vargas, Liliana ^{[1
,2
]}

Mauleon, Ana ^{[1
,2
]}

Sanchez, Domingo ^{[1
,2
]}

Martin, Elvira ^{[1
,2
]}

Rentz, Dorene M. ^{[4
]}

Lomena, Francisco ^{[5
]}

Ruiz, Agustin ^{[1
,2
]}

Tarraga, Lluis ^{[1
,2
]}

Boada, Merce ^{[1
,2
]}

机构：

[1] Fundacio ACE, Alzheimer Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

[2] Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona, Spain

[3] Univ Autonoma Barcelona, CIBERSAM, Hosp Univ Vall dHebron, Psychiat Dept, Barcelona, Spain

[4] Harvard Med Sch, Brigham & Womens Hosp, Massachusetts Gen Hosp, Ctr Alzheimer Res & Treatment,Dept Neurol, Boston, MA USA

[5] Hosp Clin Barcelona, Serv Med Nucl, Barcelona, Spain

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

MINI-MENTAL STATE; ALZHEIMERS-DISEASE; VERBAL FLUENCY; IMPAIRMENT; COMPLAINTS; OLDER; DEMENTIA; VALIDATION; RISK; INDIVIDUALS;

D O I：

10.1038/s41598-018-21644-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (A beta) burden measured with Positron-Emission-Tomography using C-11-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with A beta burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18) F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure A beta burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to A beta deposition. Higher global A beta deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher A beta deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.

引用

页数：9

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