Development of the Paris Definition of Early Crohn's Disease for Disease-Modification Trials: Results of an International Expert Opinion Process

被引：82

作者：

Peyrin-Biroulet, Laurent ^{[1
,2
]}

Billioud, Vincent ^{[1
,2
]}

D'Haens, Geert ^{[3
]}

Panaccione, Remo ^{[4
]}

Feagan, Brian ^{[5
,6
]}

Panes, Julian ^{[7
]}

Danese, Silvio ^{[8
]}

Schreiber, Stefan ^{[9
]}

Ogata, Haruhiko ^{[10
]}

Hibi, Toshifumi ^{[10
]}

Higgins, Peter D. R. ^{[11
]}

Beaugerie, Laurent ^{[12
,13
]}

Chowers, Yehuda ^{[14
,15
]}

Louis, Edouard ^{[16
,17
]}

Steinwurz, Flavio ^{[18
]}

Reinisch, Walter ^{[19
]}

Rutgeerts, Paul ^{[20
]}

Colombel, Jean-Frederic ^{[21
]}

Travis, Simon ^{[22
]}

Sandborn, William J. ^{[23
]}

机构：

[1] Univ Henri Poincare 1, INSERM, U954, F-54511 Vandoeuvre Les Nancy, France

[2] Univ Henri Poincare 1, Univ Hosp Nancy, Dept Hepatogastroenterol, F-54511 Vandoeuvre Les Nancy, France

[3] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Calgary, Inflammatory Bowel Dis Clin, Calgary, AB, Canada

[5] Robarts Res Inst, London, ON N6A 5C1, Canada

[6] Univ Western Ontario, London, ON, Canada

[7] CIBERehd, IDIBAPS, Hosp Clin, Dept Gastroenterol, Barcelona, Spain

[8] Ist Clin Humanitas, Dept Gastroenterol, Rozzano, Italy

[9] Univ Kiel, Univ Hosp Kiel, Kiel, Germany

[10] Keio Univ, Sch Med, Tokyo, Japan

[11] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[12] Univ Paris, Univ Paris 06, F-75252 Paris, France

[13] Univ Paris, Hop St Antoine, AP HP, Dept Gastroenterol, F-75252 Paris, France

[14] Dept Gastroenterol, Haifa, Israel

[15] Technion Israel Inst Technol, Bruce Rappaport Sch Med, Haifa, Israel

[16] Univ Liege, CHU Liege, Dept Gastroenterol, Liege, Belgium

[17] Univ Liege, GIGA Res, Liege, Belgium

[18] Hosp Israelita Albert Einstein, Sao Paulo, Brazil

[19] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria

[20] Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium

[21] Univ Lille Nord France, CHU Lille, Lille, France

[22] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[23] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 107卷 / 12期

关键词：

EARLY MULTIPLE-SCLEROSIS; INTESTINAL FIBROSIS; BOWEL OBSTRUCTION; NATURAL-HISTORY; RISK-FACTORS; COMPLICATIONS; REMISSION; THERAPY; CLASSIFICATION; INFLAMMATION;

D O I：

10.1038/ajg.2012.117

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. Am J Gastroenterol 2012;107:1770-1776; doi:10.1038/ajg.2012.117

引用

页码：1770 / 1776

页数：7

共 30 条

[1] Early Crohn disease: a proposed definition for use in disease-modification trials
Peyrin-Biroulet, Laurent
Loftus, Edward V., Jr.
Colombel, Jean-Frederic
Sandborn, William J.
GUT, 2010, 59 (02) : 141 - 147
[2] Early intervention in Crohn's disease: towards disease modification trials
Danese, Silvio
Fiorino, Gionata
Peyrin-Biroulet, Laurent
GUT, 2017, 66 (12) : 2179 - 2187
[3] A review and expert opinion of the use of certolizumab for Crohn's disease
Evans, Ashley T.
Lee, Scott D.
EXPERT OPINION ON BIOLOGICAL THERAPY, 2012, 12 (03) : 363 - 370
[4] Appropriate maintenance treatment for Crohn's disease: Results of a multidisciplinary international expert panel - EPACT II
Juillerat, Pascal
Vader, John-Paul
Felley, Christian
Pittet, Valerie
Gonvers, Jean-Jacques
Mottet, Christian
Bemelman, Willem A.
Lemann, Marc
Oresland, Tom
Michetti, Pierre
Froehlich, Florian
Grp, E. P. A. C. T. I. I. Study
JOURNAL OF CROHNS & COLITIS, 2009, 3 (04) : 241 - 249
[5] Endpoints for Clinical Trials Evaluating Disease Modification and Structural Damage in Adults with Crohn's Disease
D'Haens, Geert R.
Fedorak, Richard
Lemann, Marc
Feagan, Brian G.
Kamm, Michael A.
Cosnes, Jacques
Rutgeerts, Paul J.
Marteau, Philippe
Travis, Simon
Schoelmerich, Juergen
Hanauer, Steven
Sandborn, William J.
INFLAMMATORY BOWEL DISEASES, 2009, 15 (10) : 1599 - 1604
[6] Appropriate treatment for Crohn's disease: Methodology and summary results of a multidisciplinary international expert panel approach - EPACT
Vader, J. -R
Froehlich, F.
Juillerat, R.
Burnand, B.
Felley, C.
Gonvers, J. -J.
Mottet, C.
Pittet, V.
Dubois, R. W.
Wietlisbach, V.
Michetti, P.
DIGESTION, 2006, 73 (04) : 237 - 248
[7] Appropriateness of therapy for active Crohn's disease: Results of a multidisciplinary international expert panel-EPACT II
Michetti, Pierre
Stelle, Marc
Juillerat, Pascal
Gassull, Miquel
Heil, Franz Josef
Stange, Eduard
Mottet, Christian
Gonvers, Jean-Jacques
Pittet, Valerie
Vader, John-Paul
Froehlich, Florian
Felley, Christian
JOURNAL OF CROHNS & COLITIS, 2009, 3 (04) : 232 - 240
[8] Crohn's disease prognosis and early immunomodulator therapy: Results from the CONNECT study
Kim, Bun
Cheon, Jae Hee
Moon, Hyun Jin
Park, Yi Rang
Ye, Byong Duk
Yang, Suk-Kyun
Seo, Geom Seog
Jang, Byung Ik
Kim, You Sun
Kim, Joo Sung
Han, Dong Soo
Kim, Young-Ho
Kim, Won Ho
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 (01) : 126 - 132
[9] Editorial: an expert consensus to standardise the assessment of histologic disease activity in Crohn's disease clinical trials-a missing link
Mantzaris, Gerassimos J.
Bamias, Giorgos
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2021, 53 (06) : 749 - 750
[10] Early perioperative results and surgical recurrence after strictureplasty and miniresection for complicated Crohn's disease
Sampietro, GM
Cristaldi, M
Porretta, T
Montecamozzo, G
Danelli, P
Taschieri, AM
DIGESTIVE SURGERY, 2000, 17 (03) : 261 - 267

← 1 2 3 →