Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

被引：23

作者：

Nemr, Rita ^{[2
]}

Turki, Amira ^{[3
]}

Echtay, Akram ^{[4
]}

Al-Zaben, Ghadeer S.

Daher, Hoda S.

Irani-Hakime, Noha A. ^{[5
]}

Keleshian, Sose H. ^{[5
]}

Almawi, Wassim Y. ^{[1
]}

机构：

[1] Arabian Gulf Univ, Coll Med & Med Sci, Dept Med Biochem, Manama, Bahrain

[2] Univ Med Ctr Rizk Hosp, Dept Endocrinol, Beirut, Lebanon

[3] Univ Monastir, Fac Pharm Monastir, Monastir, Tunisia

[4] Rafic Hariri Univ Hosp, Dept Endocrinol, Beirut, Lebanon

[5] St Georges Univ Hosp, Dept Lab Med, Beirut, Lebanon

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2012年 / 98卷 / 03期

关键词：

Diabetes; Genome wide association; Replication; TCF7L2; TCF7L2; GENE; JAPANESE POPULATION; ARAB POPULATION; COMMON VARIANTS; REPLICATION; RISK; POLYMORPHISMS; MELLITUS; GLUCOSE;

D O I：

10.1016/j.diabres.2012.09.044

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E23 / E27

页数：5

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