Charge Transport within a Three-Dimensional DNA Nanostructure Framework

被引：122

作者：

Lu, Na ^{[3
,4
,5
]}

Pei, Hao ^{[3
]}

Ge, Zhilei ^{[1
,2
,3
]}

Simmons, Chad R. ^{[1
,2
]}

Yan, Hao ^{[1
,2
]}

Fan, Chunhai ^{[3
]}

机构：

[1] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[3] Chinese Acad Sci, Shanghai Inst Appl Phys, Lab Phys Biol, Shanghai 201800, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, State Key Labs Transducer Technol, Shanghai 200050, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Sci & Technol Microsyst Lab, Shanghai 200050, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 32期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-TRANSFER; HOLE-TRANSFER; DYNAMICS; KINETICS; SEQUENCE; SENSOR;

D O I：

10.1021/ja302447r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three-dimensional (3D) DNA nanostructures have shown great promise for various applications including molecular sensing and therapeutics. Here we report kinetic studies of DNA-mediated charge transport (CT) within a 3D DNA nanostructure framework. A tetrahedral DNA nanostructure was used to investigate the through-duplex and through-space CT of small redox molecules (methylene blue (MB) and ferrocene (Fc)) that were bound to specific positions above the surface of the gold electrode. CT rate measurements provide unambiguous evidence that the intercalative MB probe undergoes efficient mediated CT over longer distances along the duplex, whereas the nonintercalative Fc probe tunnels electrons through the space. This study sheds new light on DNA-based molecular electronics and on designing high-performance biosensor devices.

引用

页码：13148 / 13151

页数：4

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