Evaluation of Left Ventricular Outflow Tract Obstruction With Four-Dimensional Phase Contrast Magnetic Resonance Imaging in Patients with Hypertrophic Cardiomyopathy-A Pilot Study

被引：4
作者：
Chu, Linda C. [1 ]
Porter, Kristin K. [1 ]
Corona-Villalobos, Celia Pamela [1 ]
Gulsun, Mehmet Akif [2 ]
Shea, Steven M. [2 ,3 ,4 ]
Markl, Michael
Abraham, Theodore P. [5 ]
Bluemke, David A. [6 ]
Kamel, Ihab R. [1 ]
Zimmerman, Stefan L. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Halsted B168,600 N Wolfe St, Baltimore, MD 21287 USA
[2] Siemens Corp, Corp Technol, Imaging & Comp Vis, Princeton, NJ USA
[3] Loyola Univ, Stritch Sch Med, Dept Radiol, Chicago, IL 60611 USA
[4] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[5] Johns Hopkins Univ, Sch Med, Dept Cardiol, Baltimore, MD USA
[6] NIH, Radiol & Imaging Sci, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA
来源：
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY | 2016年 / 40卷 / 06期
关键词：
hypertrophic cardiomyopathy; cardiac magnetic resonance; four-dimensional phase contrast; left ventricular outflow tract obstruction; FLOW PATTERNS; AORTIC FLOW; HEART;
D O I：
10.1097/RCT.0000000000000471
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective: This study aimed to validate 4-dimensional phase contrast (4D PC) cine magnetic resonance imaging (MRI) as a means of evaluating left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic cardiomyopathy (HCM). Methods: In this institutional review board-approved prospective study, 23 patients with suspected HCM from October 2012 to September 2013 underwent 4D PC MRI. Postprocessed 4D PC pathline cine data were reviewed by 2 blinded reviewers to determine presence or absence of LVOT obstruction. Sensitivity, specificity, and accuracy in 4D PC qualitative and quantitative assessment of LVOT obstruction were calculated using echo as reference standard. Results: Consensus interpretation of 4D PC showed 100.0% (7/7) sensitivity, 75.0% specificity (12/16), and 82.6% (19/23) accuracy in assessment of LVOT obstruction. The 4D PC quantitative estimates of LVOT gradient have 71.4% (5/7) sensitivity, 93.8% (15/16) specificity, and 87.0% (20/23) accuracy in evaluation of LVOT obstruction compared with echo. Conclusions: The 4D PC MRI can assess for LVOT obstruction in HCM patients.
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收藏
页码：937 / 940
页数：4
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