Electrochemically Driven, Electrode-Addressable Formation of Functionalized Polydopamine Films for Neural Interfaces

被引：66

作者：

Kang, Kyungtae ^{[1
]}

Lee, Seokyoung ^{[2
]}

Kim, Raeyoung ^{[2
]}

Choi, Insung S. ^{[1
,2
]}

Nam, Yoonkey ^{[2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Cell Encapsulat Res, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 52期

基金：

新加坡国家研究基金会;

关键词：

biofunctionalization; electrodes; microelectrode arrays; neurochemistry; polydopamine; SELF-ASSEMBLED MONOLAYERS; CONDUCTING POLYMERS; SURFACES; BIOMOLECULES; COATINGS; ADHESION; PLATFORM; ARRAYS; CELLS;

D O I：

10.1002/anie.201207129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a simple but versatile method for simultaneously coating and functionalizing a specific electrode in the MEAwith a spatial resolution based on electrochemical polymerization of dopamine under slightly acidic conditions. The electrode-selective functionalization has a great impact to the multiplexed sensing systems and the asymmetrical manipulation of cells, which is particularly important in the neural interfaces. The functionalized polydopamine layer on the electrode was found to be suitable for neural attachment and development without a loss of the electrical properties of the electrode. We believe that the method demonstrated herein would provide a solid platform for multiplexed detection of neuronal responses as well as molecular targets. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13101 / 13104

页数：4

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