Heterogeneous occurrence of aquaporin-4 in the ependyma and in the circumventricular organs in rat and chicken

被引:32
作者
Goren, O [1 ]
Adorján, I [1 ]
Kálmán, M [1 ]
机构
[1] Semmelweis Univ, Dept Anat Histol & Embryol, H-1094 Budapest, Hungary
来源
ANATOMY AND EMBRYOLOGY | 2006年 / 211卷 / 02期
关键词
ependymal organs; hypendymal organs; GFAP; median eminence; pineal body; subcommissural organ; subtrochlear organ;
D O I
10.1007/s00429-005-0067-8
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Aquaporins are selective water channel proteins critical in volume homeostasis. In the CNS AQP4 predominates, localized mainly in the glia limitans, the perivascular endfeet and ependyma. The present immunofluorescent study reveals the distribution of aquaporin-4 in the circumventricular organs in rat and chicken brains. The ventricular ependyma (especially in the third one), the subfornical organ, the area postrema, the rat pineal body (in part), and the vascular organ of lamina terminalis were marked by intense immunopositivity. Several areas, however, proved to be immunonegative: the central canal, the subcommissural organ, the ependymal zone of the median eminence in rat but its whole thickness in chicken, the subtrochlear organ, and the paraventricular organ. The immunostaining of the lateral septal and subseptal organs were similar to their environment. Results on developing rats suggested that the aquaporin-4 immunonegativity is a secondary phenomenon. Surveying other structural and functional features, no clear explanation of the heterogeneous occurrence of aquaporin-4 was found. The absence of aquaporin-4 seems to correlate with some features of the "ependymal organs" (thickened, pseudostratified ependyma, presence of blood-brain barrier) and with the avoidance of GFAP. On the other hand, the organs rich in aquaporin-4 have features of the "hypendymal organs" (glial and vascular plexus but no blood-brain barrier). There are organs, however, which do not fit into either group completely, i.e. the lateral septal and subseptal organs. Presence of tight junctions coincides with the absence of aquaporin-4 in the ependyma of spinal cord, the subcommissural organ and the ependyma of median eminence.
引用
收藏
页码:155 / 172
页数:18
相关论文
共 88 条
  • [1] Aquaporin water channels - from atomic structure to clinical medicine
    Agre, P
    King, LS
    Yasui, M
    Guggino, WB
    Ottersen, OP
    Fujiyoshi, Y
    Engel, A
    Nielsen, S
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2002, 542 (01): : 3 - 16
  • [2] Aquaporin water channels: molecular mechanisms for human diseases
    Agre, P
    Kozono, D
    [J]. FEBS LETTERS, 2003, 555 (01): : 72 - 78
  • [3] The molecular basis of water transport in the brain
    Amiry-Moghaddam, M
    Ottersen, OP
    [J]. NATURE REVIEWS NEUROSCIENCE, 2003, 4 (12) : 991 - 1001
  • [4] An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain
    Amiry-Moghaddam, M
    Otsuka, T
    Hurn, PD
    Traystman, RJ
    Haug, FM
    Froehner, SC
    Adams, ME
    Neely, JD
    Agre, P
    Ottersen, OPT
    Bhardwaj, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) : 2106 - 2111
  • [5] [Anonymous], 1986, ASTROCYTES, DOI DOI 10.1016/B978-0-12-250451-8.50018-7
  • [6] Distribution of aquaporin 9 in the adult rat brain: Preferential expression in catecholaminergic neurons and in glial cells
    Badaut, J
    Petit, JM
    Brunet, JF
    Magistretti, PJ
    Charriaut-Marlangue, C
    Regli, L
    [J]. NEUROSCIENCE, 2004, 128 (01) : 27 - 38
  • [7] Use of a heterologous monoclonal antibody for cloning and detection of glial fibrillary acidic protein in the bovine ventricular ependyma
    Bouchard, P
    Ravet, V
    Meiniel, R
    Creveaux, I
    Meiniel, A
    Vellet, A
    Vigues, B
    [J]. CELL AND TISSUE RESEARCH, 1999, 298 (02) : 207 - 216
  • [8] JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN VERTEBRATE BRAIN
    BRIGHTMA.MW
    REESE, TS
    [J]. JOURNAL OF CELL BIOLOGY, 1969, 40 (03) : 648 - +
  • [9] DEVELOPMENTAL EXPRESSION OF GLIAL MARKERS IN EPENDYMOCYTES OF THE RAT SUBCOMMISSURAL ORGAN - ROLE OF THE ENVIRONMENT
    CHOUAF, L
    DIDIERBAZES, M
    HARDIN, H
    AGUERA, M
    FEVREMONTANGE, M
    VOUTSINOS, B
    BELIN, MF
    [J]. CELL AND TISSUE RESEARCH, 1991, 266 (03) : 553 - 561
  • [10] IMMUNOCYTOCHEMICAL LOCALIZATION OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IN THE AREA POSTREMA OF THE CAT - LIGHT AND ELECTRON-MICROSCOPIC STUDY
    DAMELIO, FE
    GIBBS, MA
    MEHLER, WR
    ENG, LF
    [J]. BRAIN RESEARCH, 1985, 330 (01) : 146 - 149