Antiviral therapy: old and current issues

被引：47
作者：
Antonelli, Guido [1 ]
Turriziani, Ombretta [1 ]
机构：
[1] Univ Roma La Sapienza, Virol Lab, Dept Mol Med, I-00185 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 40卷 / 02期
关键词：
Antiviral drugs; Antiviral therapy; HIV; Antiviral agents; Antiviral activity; Virus; INFLUENZA-VIRUS NEURAMINIDASE; RESPIRATORY SYNCYTIAL VIRUS; ZINC-FINGER NUCLEASES; DOUBLE-BLIND; ANTIRETROVIRAL THERAPY; GENITAL HERPES; GENE-THERAPY; HIV; INHIBITORS; ACYCLOVIR;
D O I：
10.1016/j.ijantimicag.2012.04.005
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Many antiviral drugs are currently approved and formally licensed for clinical use in the treatment of viral infections caused by human immunodeficiency virus, herpes simplex viruses, varicella-zoster virus, respiratory syncytial virus, cytomegalovirus, hepatitis B virus, hepatitis C virus or influenza virus. Recent decades have seen major advances in our knowledge of the natural history and pathogenesis of viral diseases as well as ongoing developments and improvements in antiviral therapy. However, research is far from complete and indeed previously unknown and unexpected issues are currently arising. This review aims to discuss some of these issues in the belief that they should be carefully addressed to enhance the management of patients with viral infections. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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页码：95 / 102
页数：8
相关论文
共 84 条
[1]   Nonnucleoside Reverse Transcriptase Inhibitor Resistance and the Role of the Second-Generation Agents [J].
Adams, Jessica ;
Patel, Nimish ;
Mankaryous, Nancy ;
Tadros, Mariam ;
Miller, Christopher D. .
ANNALS OF PHARMACOTHERAPY, 2010, 44 (01) :157-165
[2]   TREATMENT OF INFECTIONS DUE TO HERPESVIRUS IN HUMANS - CRITICAL-REVIEW OF STATE OF ART [J].
ALFORD, CA ;
WHITLEY, RJ .
JOURNAL OF INFECTIOUS DISEASES, 1976, 133 :A101-A108
[3]  
Antonelli G, 2008, NEW MICROBIOL, V31, P305
[4]   Antiviral drugs [J].
Balfour, HH .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (16) :1255-1268
[5]   Interferons at age 50: past, current and future impact on biomedicine [J].
Borden, Ernest C. ;
Sen, Ganes C. ;
Uze, Gilles ;
Silverman, Robert H. ;
Ransohoff, Richard M. ;
Foster, Graham R. ;
Stark, George R. .
NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (12) :975-990
[6]  
Centers for Disease Control and Prevention (CDC), 2006, MMWR Morb Mortal Wkly Rep, V55, P592
[7]   Hypersensitivity reactions to HIV therapy [J].
Chaponda, Mas ;
Pirmohamed, Munir .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 71 (05) :659-671
[8]  
Chen WZ, 2012, AIDS RES HUM RETROV, V28, P425, DOI [10.1089/AID.2011.0226, 10.1089/aid.2011.0226]
[9]   Antiherpesvirus drugs: A promising spectrum of new drugs and drug targets [J].
Coen, DM ;
Schaffer, PA .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (04) :278-288
[10]   Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs [J].
Coiras, Mayte ;
Rosa Lopez-Huertas, Maria ;
Perez-Olmeda, Mayte ;
Alcami, Jose .
NATURE REVIEWS MICROBIOLOGY, 2009, 7 (11) :798-812
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