Quantity and Quality of Antibodies After Acellular Versus Whole-cell Pertussis Vaccines in Infants Born to Mothers Who Received Tetanus, Diphtheria, and Acellular Pertussis Vaccine During Pregnancy: A Randomized Trial

被引：41

作者：

Wanlapakorn, Nasamon ^{[1
,2
]}

Maertens, Kirsten ^{[3
]}

Vongpunsawad, Sompong ^{[1
]}

Puenpa, Jiratchaya ^{[1
]}

Thao Mai Phuong Tran ^{[4
]}

Hens, Niel ^{[4
,5
]}

Van Damme, Pierre ^{[3
]}

Thiriard, Anais ^{[6
]}

Raze, Dominique ^{[6
]}

Locht, Camille ^{[6
]}

Poovorawan, Yong ^{[1
]}

Leuridan, Elke ^{[3
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Dept Pediat, Bangkok, Thailand

[2] Chulalongkorn Univ, Div Acad Affairs, Fac Med, Bangkok, Thailand

[3] Univ Antwerp, Fac Med & Hlth Sci, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, Univ Pl 1, B-2610 Antwerp, Belgium

[4] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium

[5] Univ Antwerp, Ctr Hlth Econ Res & Modelling Infect Dis, Vaccine & Infect Dis Inst, Antwerp, Belgium

[6] Univ Lille, Ctr Hosp Reg Univ Lille, CNRS,Inst Pasteur Lille, Ctr Infect & Immun Lille,U1019 UMR8204,INSERM, Lille, France

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 01期

基金：

欧洲研究理事会;

关键词：

pertussis; pregnancy; maternal immunization; humoral immune response; functionality; PRIMARY IMMUNIZATION; IMMUNE-RESPONSES; IMMUNOGENICITY; TDAP; IMPACT; WOMEN;

D O I：

10.1093/cid/ciz778

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The blunting effect of pertussis immunization during pregnancy on infant antibody responses induced by whole-cell pertussis (wP) vaccination is not well-defined. Methods. This randomized controlled trial (NCT02408926) followed term infants born to mothers vaccinated with tetanus, diphtheria, and acellular pertussis (Tdap) vaccine during pregnancy in Thailand. Infants received either acellular pertussis (aP)- or wP-containing vaccine at 2, 4, 6, and 18 months of age. A comparison group comprised wP-vaccinated children born to mothers not vaccinated during pregnancy. Antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) were evaluated using commercial enzyme-linked immunosorbent assays. Functionality of antibodies against Bordetella pertussis was measured using Bordetella pertussis growth inhibition assay. Results. After maternal Tdap vaccination, 158 infants vaccinated with aP-containing vaccines possessed higher antibody levels (P < .001) against all tested B. pertussis antigens postpriming compared to 157 infants receiving wP-containing vaccines. At 1 month postbooster, only anti-FHA and anti-PRN antibodies were still significantly higher (P < .001) in the aP group. Significantly higher anti-PT and anti-FHA (P < .001), but not anti-PRN immunoglobulin G, were observed among 69 wP-vaccinated infants born to control mothers compared with wP-vaccinated infants of Tdap-vaccinated mothers after primary and booster vaccination. The antibody functionality was higher in all wP-vaccinated infants at all times. Conclusions. Maternal Tdap vaccination inhibited more pertussis-specific responses in wP-vaccinated infants compared to aP-vaccinated infants, and the control group of unvaccinated women had highest PT-specific responses, persisting until after the booster dose. Antibody functionality was better in the wP groups.

引用

页码：72 / 80

页数：9

共 36 条

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