Allogeneic hematopoietic stem cell transplantation versus hypomethylating agents in patients with myelodysplastic syndrome: A retrospective casecontrol study

被引：8

作者：

Jabbour, Elias ^{[1
,2
]}

Mathisen, Michael S. ^{[1
,2
]}

Garcia-Manero, Guillermo ^{[1
,2
]}

Champlin, Richard ^{[1
,2
]}

Popat, Uday ^{[1
,2
]}

Khouri, Issa ^{[1
,2
]}

Giralt, Sergio ^{[3
]}

Kadia, Tapan ^{[1
,2
]}

Chen, Julianne ^{[1
,2
]}

Pierce, Sherry ^{[1
,2
]}

Koca, Ebru ^{[1
,2
]}

Daver, Naval ^{[1
,2
]}

Tanaka, Maria ^{[1
,2
]}

Rondon, Gabriela ^{[1
,2
]}

Oran, Betul ^{[1
,2
]}

Parmar, Simrit ^{[1
,2
]}

Kantarjian, Hagop ^{[1
,2
]}

de Lima, Marcos ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[3] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2013年 / 88卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; SCORING SYSTEM; AZACITIDINE; DECITABINE; THERAPY;

D O I：

10.1002/ajh.23371

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment for myelodysplastic syndrome (MDS). Recently, hypomethylating agents (HMAs) have been shown to improve survival in patients with high-risk MDS. We conducted a retrospective casecontrol study to compare survival with these treatment modalities in patients with untreated MDS. Controls were identified using a departmental database and transplant patients were matched in at least three of the following five criteria: year of diagnosis, age, blast percentage, International Prognostic Scoring System cytogenetic risk, and time from diagnosis to treatment. Median overall survival (OS) was 26 and 25 months for, respectively, allo-SCT [(n = 53); range, 2210 months] and HMA [(n = 40); range, 298 months] (P = 0.89). Four-year survival rates were 24 and 23% for allo-SCT patients and the nontransplant cohort, respectively. Patients undergoing allo-SCT after 2000 had longer median OS compared with those transplanted before 2000 (41 versus 7 months, P=0.001). These results would suggest that prospective studies are needed to delineate the timing and efficacy of allo-SCT in the HMA era. Am. J. Hematol. 88:198200, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：198 / 200

页数：3

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