Effects of a neurokinin-1 receptor (NK-1R) antagonist on colon cancer through suppression of colon tumor-initiating cells

被引:0
|
作者
Polytarchou, C.
Bugni, J. M.
Dry, S.
Pothoulakis, C.
Iliopoulos, D.
机构
[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Pathol, Translat Pathol Core Lab, Los Angeles, CA 90024 USA
关键词
D O I
10.1200/jco.2011.29.15_suppl.3614
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3614
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance
    Garcia-Aranda, Marilina
    Tellez, Teresa
    McKenna, Lauraine
    Redondo, Maximino
    CANCERS, 2022, 14 (09)
  • [2] Protein expression of the truncated neurokinin-1 receptor (NK-1R) is increased in dysplastic and malignant epithelial cells from patients with colitis associated colon cancer (CAC)
    Gillespie, Earl
    Stucchi, Arthur
    O'Brien, Michael
    Cerda, Sandra
    Farraye, Francis A.
    Coukos, Jennifer
    Watts, Luisa
    Leeman, Susan
    Becker, James M.
    FASEB JOURNAL, 2011, 25
  • [3] The Potential In Vitro Inhibitory Effects of Neurokinin-1 Receptor (NK-1R) Antagonist, Aprepitant, in Osteosarcoma Cell Migration and Metastasis
    Alsaeed, Mohammed Ali
    Ebrahimi, Safieh
    Alalikhan, Abbas
    Hashemi, Seyedeh Fatemeh
    Hashemy, Seyed Isaac
    BIOMED RESEARCH INTERNATIONAL, 2022, 2022
  • [4] Neurokinin-1 receptor (NK-1R) antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme
    Afshari, Amir R.
    Motamed-Sanaye, Ali
    Sabri, Hamed
    Soltani, Arash
    Karkon-Shayan, Sepideh
    Radvar, Sarvin
    Javid, Hossein
    Mollazadeh, Hamid
    Sathyapalan, Thozhukat
    Sahebkar, Amirhossein
    CURRENT MEDICINAL CHEMISTRY, 2021, 28 (24) : 4877 - 4892
  • [5] Truncated Neurokinin-1 Receptor Mediates Colon Cancer Development
    Koon, Hon Wai
    Bugni, James M.
    Zhao, Dezheng
    Kumar, Aatish
    Xu, Hua
    Pothoulakis, Charalabos
    GASTROENTEROLOGY, 2009, 136 (05) : A465 - A465
  • [6] Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells
    Garnier, Agnes
    Vykoukal, Jody
    Hubertus, Jochen
    Alt, Eckhard
    Von Schweinitz, Dietrich
    Kappler, Roland
    Berger, Michael
    Ilmer, Matthias
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 47 (01) : 151 - 160
  • [7] Effect of a Neurokinin-1 Receptor Antagonist in a Rat Model of Colitis-Associated Colon Cancer
    Pagan, Beatriz
    Isidro, Angel A.
    Coppola, Domenico
    Chen, Zhengming
    Ren, Yuan
    Wu, Jie
    Appleyard, Caroline B.
    ANTICANCER RESEARCH, 2010, 30 (09) : 3345 - 3353
  • [8] Neurokinin-1 receptor expression and antagonism by the NK-1R antagonist maropitant in canine melanoma cell lines and primary tumour tissues
    Borrego, J. F.
    Huelsmeyer, M. K.
    Pinkerton, M. E.
    Muszynski, J. L.
    Miller, S. A. K.
    Kurzman, I. D.
    Vail, D. M.
    VETERINARY AND COMPARATIVE ONCOLOGY, 2016, 14 (02) : 210 - 224
  • [9] Identification of a NK-1R Antagonist as a Novel Therapeutic Approach in Colon Cancer by High Throughput Chemical Screening
    Polytarchou, Christos
    Palumbo, Tiziana
    Bugni, James M.
    Pothoulakis, Charalabos
    Iliopoulos, Dimitrios
    GASTROENTEROLOGY, 2012, 142 (05) : S117 - S118
  • [10] Biological and Genetic Characteristics of Tumor-Initiating Cells in Colon Cancer
    Keisuke Ieta
    Fumiaki Tanaka
    Naotsugu Haraguchi
    Yoshiaki Kita
    Hiroyuki Sakashita
    Koshi Mimori
    Toshifumi Matsumoto
    Hiroshi Inoue
    Hiroyuki Kuwano
    Masaki Mori
    Annals of Surgical Oncology, 2008, 15 : 638 - 648