Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides

被引：65
|
作者：
Rajanarendar, E. [1 ]
Raju, S. [1 ]
Reddy, M. Nagi [1 ]
Krishna, S. Rama [1 ]
Kiran, L. Hari [2 ]
Reddy, A. Ram Narasimha [2 ]
Reddy, Y. Narasimha [2 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
[2] Kakatiya Univ, Dept Pharmacol & Toxicol, Warangal 506009, Andhra Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 50卷
关键词：
Novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides; Multi-component synthesis; In vitro anticancer activity; In vivo anticancer activity; MOSQUITO LARVICIDAL ACTIVITY; HUMAN-IMMUNODEFICIENCY-VIRUS; NITRIC-OXIDE; DERIVATIVES; INHIBITION;
D O I：
10.1016/j.ejmech.2012.02.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies. (C) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：274 / 279
页数：6
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