Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation

被引：49

作者：

Moody, Catherine L. ^{[1
]}

Franckevicius, Vilius ^{[1
]}

Drouhin, Pauline ^{[1
]}

Klein, Johannes E. M. N. ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 15期

关键词：

Copper catalysis; Spirocyclic oxindoles; Radical cyclisation; C-H activation; Natural product synthesis; ANION CAPTURE PROCESSES; ENANTIOSELECTIVE SYNTHESIS; SUBSTITUTED OXINDOLES; ALPHA-ARYLATION; PALLADIUM; SPIROOXINDOLES; GELSEMINE; CENTERS; AMIDES; DERIVATIVES;

D O I：

10.1016/j.tetlet.2012.01.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1897 / 1899

页数：3

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