Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies

被引：13

作者：

Ali, Esraa ^{[1
]}

Trailin, Andriy ^{[1
]}

Ambrozkiewicz, Filip ^{[1
]}

Liska, Vaclav ^{[2
,3
,4
]}

Hemminki, Kari ^{[1
,5
]}

机构：

[1] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Lab Translat Canc Genom, Alej Svobody 1665-76, Plzen 32300, Czech Republic

[2] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Lab Canc Treatment & Tissue Regenerat, Alej Svobody 1665-76, Plzen 32300, Czech Republic

[3] Charles Univ Prague, Univ Hosp, Dept Surg, Alej Svobody 80, Plzen 32300, Czech Republic

[4] Charles Univ Prague, Fac Med Pilsen, Alej Svobody 80, Plzen 32300, Czech Republic

[5] German Canc Res Ctr, Dept Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期

基金：

欧盟地平线“2020”;

关键词：

hepatocellular carcinoma; hepatic stellate cells; fibrosis regression; therapeutic studies; NATURAL-KILLER-CELLS; EXTRACELLULAR-MATRIX; RADIOFREQUENCY ABLATION; LIVER FIBROSIS; APOPTOSIS; RADIOTHERAPY; RESISTANCE; SORAFENIB; MIGRATION; ETIOLOGY;

D O I：

10.3390/ijms232315292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interaction with different immune cells. They also increase the deposition of the extracellular matrix proteins, challenging the reversion of fibrosis and increasing HCC growth and metastasis. Therapy for HCC was reported to activate HSCs, which could explain the low efficacy of current treatments. Conversely, recent studies aimed at the deactivation of HSCs show that they have been able to inhibit HCC growth. In this review article, we discuss the role of aHSCs in HCC pathophysiology and therapy. Finally, we provide suggestions for the experimental implementation of HSCs in HCC therapies.

引用

页数：11

共 81 条

[1] The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer [J].