Synthesis of graphene quantum dots and their applications in drug delivery

被引：233
作者：
Zhao, Changhong [1 ,2 ]
Song, Xuebin [1 ]
Liu, Ya [2 ]
Fu, Yifeng [2 ]
Ye, Lilei [3 ]
Wang, Nan [3 ]
Wang, Fan [1 ]
Li, Lu [1 ]
Mohammadniaei, Mohsen [4 ]
Zhang, Ming [4 ]
Zhang, Qiqing [1 ]
Liu, Johan [2 ,5 ]
机构：
[1] Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Henan, Peoples R China
[2] Chalmers Univ Technol, Dept Microtechnol & Nanosci, Elect Mat & Syst Lab, S-41296 Gothenburg, Sweden
[3] SHT Smart High Tech AB, S-41133 Gothenburg, Sweden
[4] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark
[5] Shanghai Univ, Sch Automat & Mech Engn, SMIT Ctr, 20 Chengzhong Rd,Box 808, Shanghai 201800, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2020年 / 18卷 / 01期
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
Graphene quantum dots; Top-down; Bottom-up; Drug delivery; Delivery-release mode; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; IN-SITU SYNTHESIS; FACILE SYNTHESIS; CARBON NANOTUBES; UP-CONVERSION; PHYSICOCHEMICAL PROPERTIES; SUSTAINABLE SYNTHESIS; HYDROTHERMAL ROUTE; SENSING PROPERTIES;
D O I：
10.1186/s12951-020-00698-z
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.
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页数：32
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