Regulation of E2F: a family of transcription factors involved in proliferation control

被引：103

作者：

Black, AR ^{[1
]}

Azizkhan-Clifford, J ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

来源：

GENE | 1999年 / 237卷 / 02期

关键词：

apoptosis; cell cycle; cell growth; retinoblastoma; transcription;

D O I：

10.1016/S0378-1119(99)00305-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Members of the E2F family of transcription factors are key participants in orchestration of the cell cycle, cell growth arrest and apoptosis. Therefore, an understanding of the regulation of E2F activity is essential for an understanding of the control of cellular proliferation. E2F activity is regulated by the retinoblastoma family of tumor suppressors and by multiple other mechanisms. This review will describe our current knowledge of these mechanisms which together constitute a highly complex network by which the cell cycle and cellular proliferation can be controlled. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：281 / 302

页数：22

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