Therapeutic opportunities of the IL-22-IL-22R1 system

被引：471

作者：

Sabat, Robert ^{[1
,2
]}

Ouyang, Wenjun ^{[3
]}

Wolk, Kerstin ^{[1
,2
]}

机构：

[1] Charite, Interdisciplinary Grp Mol Immunopathol, Inst Med Immunol, Dept Dermatol & Allergy, D-10117 Berlin, Germany

[2] Univ Hosp Charite, Res Ctr Immunosci, D-10115 Berlin, Germany

[3] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 01期

关键词：

INNATE LYMPHOID-CELLS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; PROINFLAMMATORY GENE-EXPRESSION; COLLAGEN-INDUCED ARTHRITIS; A VIRUS-INFECTION; GAMMA-DELTA T; RHEUMATOID-ARTHRITIS; INDUCIBLE FACTOR; IL-22; PRODUCTION; TH17; CELLS;

D O I：

10.1038/nrd4176

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells, including T helper 22 (T(H)22) cells, T(H)17 cells and T(H)1 cells, as well as subsets of innate lymphoid cells. Although IL-22 can act synergistically with IL-17 or tumour necrosis factor, some important functions of IL-22 are unique to this cytokine. Data obtained over the past few years indicate that the IL-22-IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis, graft-versus-host disease, certain infections and tumours, as well as in liver and pancreas damage. This Review highlights current knowledge of the biology of the IL-22-IL-22R1 system, its role in inflammation, tissue protection, regeneration and antimicrobial defence, as well as the positive and potentially negative consequences of its therapeutic modulation.

引用

页码：21 / 38

页数：18

共 173 条

[1] Acinar cells of the pancreas are a target of interleukin-22 [J].

Aggarwal, S ;

Xie, MH ;

Maruoka, M ;

Foster, J ;

Gurney, AL .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (12) :1047-1053

[2] Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts [J].

Andoh, A ;

Zhang, ZB ;

Inatomi, O ;

Fujino, S ;

Deguchi, Y ;

Araki, Y ;

Tsujikawa, T ;

Kitoh, K ;

Kim-Mitsuyama, S ;

Takayanagi, A ;

Shimizu, N ;

Fujiyama, Y .

GASTROENTEROLOGY, 2005, 129 (03) :969-984

[3] Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease [J].

Andoh, Akira ;

Shioya, Makoto ;

Nishida, Atsushi ;

Bamba, Shigeki ;

Tsujikawa, Tomoyuki ;

Kim-Mitsuyama, Shokei ;

Fujiyama, Yoshihide .

JOURNAL OF IMMUNOLOGY, 2009, 183 (01) :687-695

[4] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[5] Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria [J].

Basu, Rajatava ;

O'Quinn, Darrell B. ;

Silberger, Daniel J. ;

Schoeb, Trenton R. ;

Fouser, Lynette ;

Ouyang, Wenjun ;

Hatton, Robin D. ;

Weaver, Casey T. .

IMMUNITY, 2012, 37 (06) :1061-1075

[6] Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination [J].

Berer, Kerstin ;

Mues, Marsilius ;

Koutrolos, Michail ;

Al Rasbi, Zakeya ;

Boziki, Marina ;

Johner, Caroline ;

Wekerle, Hartmut ;

Krishnamoorthy, Gurumoorthy .

NATURE, 2011, 479 (7374) :538-U266

[7] Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A [J].

Besnard, Anne-Gaelle ;

Sabat, Robert ;

Dumoutier, Laure ;

Renauld, Jean-Christophe ;

Willart, Monique ;

Lambrecht, Bart N. ;

Teixeira, Mauro M. ;

Charron, Sabine ;

Fick, Lizette ;

Erard, Francois ;

Warszawska, Katarzyna ;

Wolk, Kerstin ;

Quesniaux, Valerie ;

Ryffel, Bernhard ;

Togbe, Dieudonnee .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (09) :1153-1163

[8] Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism [J].

Bleicher, Lucas ;

de Moura, Patricia Ribeiro ;

Watanabe, Leandra ;

Colau, Didier ;

Dumoutier, Laure ;

Renauld, Jean-Christophe ;

Polikarpov, Igor .

FEBS LETTERS, 2008, 582 (20) :2985-2992

[9] Interleukin 20: Discovery, receptor identification, and role in epidermal function [J].

Blumberg, H ;

Conklin, D ;

Xu, WF ;

Grossmann, A ;

Brender, T ;

Carollo, S ;

Eagan, M ;

Foster, D ;

Haldeman, BA ;

Hammond, A ;

Haugen, H ;

Jelinek, L ;

Kelly, JD ;

Madden, K ;

Maurer, MF ;

Parrish-Novak, J ;

Prunkard, D ;

Sexson, S ;

Sprecher, C ;

Waggie, K ;

West, J ;

Whitmore, TE ;

Yao, L ;

Kuechle, MK ;

Dale, BA ;

Chandrasekher, YA .

CELL, 2001, 104 (01) :9-19

[10] IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes [J].

Boniface, K ;

Bernard, FX ;

Garcia, M ;

Gurney, AL ;

Lecron, JC ;

Morel, F .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3695-3702

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