Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series

被引：39

作者：

Italiano, Antoine ^{[1
]}

Kind, Michele ^{[2
]}

Cioffi, Angela ^{[3
]}

Maki, Robert G. ^{[4
,5
]}

Bui, Binh ^{[1
]}

机构：

[1] Inst Bergonie, Dept Med Oncol, F-33076 Bordeaux, France

[2] Inst Bergonie, Dept Radiol, F-33076 Bordeaux, France

[3] Inst Gustave Roussy, Dept Med, Villejuif, France

[4] Mem Sloan Kettering Canc Ctr, Sarcoma Serv, New York, NY 10021 USA

[5] Mt Sinai Sch Med, New York, NY USA

来源：

TARGETED ONCOLOGY | 2013年 / 8卷 / 03期

关键词：

Desmoplastic round cell tumor; Sunitinib; Treatment;

D O I：

10.1007/s11523-012-0251-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

引用

页码：211 / 213

页数：3

共 6 条

[1] Sunitinib: From rational design to clinical efficacy
Chow, Laura Q. M.
Eckhardt, S. Gail
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (07) : 884 - 896
[2] Fletcher C DM., 2002, World Health Organisation Classification of tumours: Tumours of Soft Tissue and Bone, V3rd
[3] Froberg K, 1999, ANN CLIN LAB SCI, V29, P78
[4] Multicenter Phase II Trial of Sunitinib in the Treatment of Nongastrointestinal Stromal Tumor Sarcomas
George, Suzanne
Merriam, Priscilla
Maki, Robert G.
Van den Abbeele, Annick D.
Yap, Jeffrey T.
Akhurst, Timothy
Harmon, David C.
Bhuchar, Gauri
O'Mara, Margaret M.
D'Adamo, David R.
Morgan, Jeffrey
Schwartz, Gary K.
Wagner, Andrew J.
Butrynski, James E.
Demetri, George D.
Keohan, Mary L.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (19) : 3154 - 3160
[5] The diagnosis and management of desmoplastic small round cell tumor: a review
Hayes-Jordan, Andrea
Anderson, Peter M.
[J]. CURRENT OPINION IN ONCOLOGY, 2011, 23 (04) : 385 - 389
[6] Magnan HD, 2009, J CLIN ONCOL, V27

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