Involvement of the wrist and hand joints and tendons in an Egyptian systemic lupus erythematosus cohort

被引:1
作者
Abdel-Moniem, Omneya Mohamed-Ayman [1 ]
El-Sherif, Sherine [1 ]
Barakat, Mohamed Sami [2 ]
Mohasseb, Diaa Fahmy [1 ]
Abdel-Fattah, Yousra Hisham [1 ]
机构
[1] Alexandria Univ, Fac Med, Dept Phys Med Rheumatol & Rehabil, Alexandria, Egypt
[2] Alexandria Univ, Fac Med, Diagnost Radiol, Alexandria, Egypt
关键词
Systemic lupus erythematosus; Musculoskeletal ultrasound; Grip dynamometry; Pinch dynamometry; DEFORMING ARTHROPATHY; JACCOUDS ARTHROPATHY; ULTRASOUND; PAIN; RELIABILITY; PERFORMANCE; VALIDATION; ARTHRITIS; DAMAGE; INDEX;
D O I
10.1186/s43166-020-00030-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Systemic lupus erythematosus (SLE) patients often suffer hand function limitations even in the absence of symptoms related to joint or tendon disorders. Recent researches reported the presence of ultrasonographic (US) subclinical synovitis and tendon involvement in asymptomatic patients. We aimed to assess US patterns in SLE patients and determine their relationship with clinical assessment, disease activity and hand functional status using handheld dynamometry. Results We assessed 30 SLE patients (60 hands) using US; 21 (70%) patient had synovial hypertrophy, 8 (26%) showed a power Doppler (PD) activity, 6 (20%) had erosions and 11 (36.6%) had tendon US abnormality. Both patients with hand arthralgia/arthritis (symptomatic) and patients without arthralgia/arthritis (asymptomatic) had a statistically insignificant difference regarding the global synovitis score (p = 0.2) and disease activity (p = 0.3). However, the symptomatic group had a significantly increased number of joints with effusion (p = 0.04) and tendons involved (p = 0.04). The mean grip strength had a significant negative correlation with SLEDAI-2 K score (rs = - 0.4, p = 0.02) in the total patient group. In the asymptomatic group, a negative correlation was found between both mean grip (rs = - 0.5, p = 0.04) and pinch strength (rs = - 0.6, p = 0.01) with PD index, and mean pinch strength with the Jaccoud's arthropathy index (rs = - 0.49, p = 0.05). Conclusions SLE patients may have higher subclinical synovitis, erosions and tendon involvement than expected, which may in turn reduce hand grip and pinch strength. Disease activity may also have a negative impact on the hand grip functional strength.
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页数:8
相关论文
共 45 条
[1]   Guidelines for musculoskeletal ultrasound in rheumatology [J].
Backhaus, M ;
Burmester, GR ;
Gerber, T ;
Grassi, W ;
Machold, KP ;
Swen, WA ;
Wakefield, RJ ;
Manger, B .
ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (07) :641-649
[2]   Lupus arthritis-do we have a clinically useful classification? [J].
Ball, Elisabeth M. A. ;
Bell, Aubrey L. .
RHEUMATOLOGY, 2012, 51 (05) :771-779
[3]  
D'Agostino MA, 2017, RMD OPEN, V3, DOI 10.1136/rmdopen-2016-000428
[4]   Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study [J].
D'Agostino, Maria-Antonietta ;
Wakefield, Richard J. ;
Berner-Hammer, Hilde ;
Vittecoq, Olivier ;
Filippou, Georgios ;
Balint, Peter ;
Moeller, Ingrid ;
Iagnocco, Annamaria ;
Naredo, Esperanza ;
Ostergaard, Mikkel ;
Boers, Maarten ;
Gaillez, Corine ;
Van Holder, Karina ;
Le Bars, Manuela .
ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (10) :1763-1769
[5]   The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis [J].
Dedeoglu, Meryem ;
Gafuroglu, Umit ;
Yilmaz, Ozlem ;
Bodur, Hatice .
TURKISH JOURNAL OF RHEUMATOLOGY, 2013, 28 (02) :69-77
[6]   Pain and systemic lupus erythematosus [J].
Di Franco, M. ;
Guzzo, M. P. ;
Spinelli, F. R. ;
Atzeni, F. ;
Sarzi-Puttini, P. ;
Conti, F. ;
Iannuccelli, C. .
REUMATISMO, 2014, 66 (01) :33-38
[7]   Ultrasound in the assessment of musculoskeletal involvement in systemic lupus erythematosus: state of the art and perspectives [J].
Di Matteo, A. ;
Isidori, M. ;
Corradini, D. ;
Cipolletta, E. ;
McShane, A. ;
De Angelis, R. ;
Filippucci, E. ;
Grassi, W. .
LUPUS, 2019, 28 (05) :583-590
[8]   Systemic lupus erythematosus arthropathy: the sonographic perspective [J].
Di Matteo, A. ;
De Angelis, R. ;
Cipolletta, E. ;
Filippucci, E. ;
Grassi, W. .
LUPUS, 2018, 27 (05) :794-801
[9]  
DRAY GJ, 1989, HAND CLIN, V5, P145
[10]   Burden of Systemic Lupus Erythematosus on Employment and Work Productivity: Data From a Large Cohort in the Southeastern United States [J].
Drenkard, Cristina ;
Bao, Gaobin ;
Dennis, Greg ;
Kan, Hong J. ;
Jhingran, Priti M. ;
Molta, Charles T. ;
Lim, S. Sam .
ARTHRITIS CARE & RESEARCH, 2014, 66 (06) :878-887