Novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate regioisomers target folate receptor alpha positive ovarian cancer cells via inhibition of de novo purine nucleotide biosynthesis

被引:0
|
作者
Mitchell-Ryan, Shermaine K. [1 ]
Wang, Lei [2 ]
Orr, Steven [3 ]
Kugel, Sita [4 ]
Cherian, Christina [3 ]
Gangjee, Aleem [2 ]
Matherly, Larry H. [1 ]
机构
[1] Wayne State Univ, Sch Med, Detroit, MI USA
[2] Duquesne Univ, Pittsburgh, PA 15219 USA
[3] Barbara Ann Karmanos Canc Inst, Detroit, MI USA
[4] Massachusetts Gen Hosp, Boston, MA 02114 USA
关键词
D O I
10.1158/1538-7445.AM2013-5494
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5494
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收藏
页数:1
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