B-seco-29-nor-Limonoids from the stem barks of Toona ciliate var. yunnanensis

被引：20

作者：

Yang, Mei-Si ^{[1
]}

Hu, Sheng-Mou ^{[1
]}

Kong, Ling-Yi ^{[1
]}

Luo, Jun ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 44期

关键词：

Toona ciliate var. yunnanensis; Meliaceae; B-seco-Limonoids; Cytotoxic activity; LIMONOIDS; TRITERPENOIDS; CHEMISTRY; LEAVES;

D O I：

10.1016/j.tet.2015.09.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eight new compounds, including four rare B-seco-29-nor-limonoids, toonaciliatones A-D (1-4), and four normal B-seco-limonoids, toonaciliatones E-H (5-8), together with six known compounds (9-14), were isolated from the stem barks of Toona ciliata var. yunnanensis. Toonaciliatones A and B (1-2) are the first examples of B-seco-29-nor-limonoids without the common five-membered 4, 7-lactone. Their structures were elucidated by extensive spectroscopic analysis including UV, IR, NMR and HRMS, and the absolute configurations of isolates with alpha, beta-unsaturated ketone moiety (1, 5-7) were determined by CD exciton chirality method and electronic circular dichroism (ECD) calculation. Compounds 3 and 11 exhibited modest cytotoxicities against HL-60 and HepG2 cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：8472 / 8477

页数：6

共 25 条

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