B cells and their mediators as targets for therapy in solid tumors

被引：69

作者：

Gunderson, Andrew J. ^{[1
]}

Coussens, Lisa M. ^{[1
,2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2013年 / 319卷 / 11期

关键词：

Cancer; Inflammation; B cells; Leukocytes; Myeloid cells; HUMORAL IMMUNITY; FC-RECEPTORS; CANCER; IMMUNOTHERAPY; INFLAMMATION; LYMPHOCYTES; MALIGNANCY; REGULATORS; CARCINOMA; RITUXIMAB;

D O I：

10.1016/j.yexcr.2013.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy. (c) 2013 Elsevier Inc. All rights reserved.

引用

页码：1644 / 1649

页数：6

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