Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate

被引：18

作者：

Giner, JL ^{[1
]}

Ferris, WV ^{[1
]}

机构：

[1] SUNY Syracuse, ESF, Dept Chem, Syracuse, NY 13210 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1021/ol025661a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate, a biochemical intermediate in the deoxyxylulose pathway of isoprenoid biosynthesis, was accomplished in four steps. Bisphosphorylation of 2-C-methyl-D-erythritol 1,3-diacetate, followed by carbodlimide cyclization and deprotection, led to the title compound in 42% overall yield.

引用

页码：1225 / 1226

页数：2

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