Sex differences in pain-related behavior and expression of calcium/calmodulin-dependent protein kinase II in dorsal root ganglia of rats with diabetes type 1 and type 2

被引：20
作者：
Ferhatovic, Lejla [1 ]
Banozic, Adriana [1 ]
Kostic, Sandra [1 ]
Sapunar, Damir [1 ]
Puljak, Livia [1 ]
机构：
[1] Univ Split, Sch Med, Lab Pain Res, Split 21000, Croatia
来源：
ACTA HISTOCHEMICA | 2013年 / 115卷 / 05期
关键词：
Diabetes; Nociception; Sex difference; CaMKII; Rats; VANILLOID RECEPTOR-1; GENDER-DIFFERENCES; NEUROPATHIC PAIN; ACUTE INHIBITION; SENSORY NEURONS; ALPHA; COLOCALIZATION; POPULATION; PREVALENCE; PLASTICITY;
D O I：
10.1016/j.acthis.2012.11.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sex differences in pain-related behavior and expression of calcium/calmodulin dependent protein kinase II (CaMKII) in dorsal root ganglia were studied in rat models of Diabetes mellitus type 1 (DM1) and type 2 (DM2). DM1 was induced with 55 mg/kg streptozotocin, and DM2 with a combination of high-fat diet and 35 mg/kg of streptozotocin. Pain-related behavior was analyzed using thermal and mechanical stimuli. The expression of CaMKII was analyzed with immunofluorescence. Sexual dimorphism in glycemia, and expression of CaMKII was observed in the rat model of DM1, but not in DM2 animals. Increased expression of total CaMKII (tCaMKII) in small-diameter dorsal root ganglia neurons, which are associated with nociception, was found only in male DM1 rats. None of the animals showed increased expression of the phosphorylated alpha CaMKII isoform in small-diameter neurons. The expression of gamma and delta isoforms of CaMKII remained unchanged in all analyzed animal groups. Different patterns of glycemia and tCaMKII expression in male and female model of DM1 were not associated with sexual dimorphism in pain-related behavior. The present findings do not suggest sex-related differences in diabetic painful peripheral neuropathy in male and female diabetic rats. (C) 2012 Elsevier GmbH. All rights reserved.
引用
收藏
页码：496 / 504
页数：9
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